Publications Listing – TBBCF Sponsored Research

The research sponsored by the Terri Brodeur Breast Cancer Foundation has produced a number of advances that have been published in some of the world’s most prestigious journals. Here are some of the most recent scientific papers that acknowledge support from our Foundation.

Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK. Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells. PLoS One. 2012;7(4):e34343.

Insik Jeon, Dongjoo Lee, Isaac J. Krauss, Samuel J. Danishefsky. A New Model for the Presentation of Tumor-Associated Antigens and the Quest for an Anticancer Vaccine: A Solution to the Synthesis Challenge via RCM. J Am Chem Soc. 2009 October 14; 131(40): 14337–14344.

Choudhury S, Almendro V, Merino VF, Wu Z, Maruyama R, Su Y, Martins FC, Fackler MJ, Bessarabova M, Kowalczyk A, Conway T, Beresford-Smith B, Macintyre G, Cheng YK, Lopez-Bujanda Z, Kaspi A, Hu R, Robens J, Nikolskaya T, Haakensen VD, Schnitt SJ, Argani P, Ethington G, Panos L, Grant M, Clark J, Herlihy W, Lin SJ, Chew G, Thompson EW, Greene-Colozzi A, Richardson AL, Rosson GD, Pike M, Garber JE, Nikolsky Y, Blum JL, Au A, Hwang ES, Tamimi RM, Michor F, Haviv I, Liu XS, Sukumar S, Polyak K. Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics. Cell Stem Cell. 2013 Jul 3;13(1):117-30.

Maruyama R, Choudhury S, Kowalczyk A, Bessarabova M, Beresford-Smith B, Conway T, Kaspi A, Wu Z, Nikolskaya T, Merino VF, Lo PK, Liu XS, Nikolsky Y, Sukumar S, Haviv I, Polyak K. Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium. PLoS Genet. 2011 Apr;7(4):e1001369.

Wu ZJ, Meyer CA, Choudhury S, Shipitsin M, Maruyama R, Bessarabova M, Nikolskaya T, Sukumar S, Schwartzman A, Liu JS, Polyak K, Liu XS. Gene expression profiling of human breast tissue samples using SAGE-Seq. Genome Res. 2010 Dec;20(12):1730-9.

Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS.PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One. 2010 Jul 23;5(7):e11729.

Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell. 2009 Oct 6;16(4):324-35.

Kutuk O, Letai A. Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells. Cell Death Differ. 2010 Oct;17(10):1624-35.

Bailey ST, Shin H, Westerling T, Liu XS, Brown M. Estrogen receptor prevents p53-dependent apoptosis in breast cancer. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18060-5.

Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev. 2014 Jul 1;28(13):1429-44.

Zhang Q*, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A* Control of Cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydoxylase. (2009). Cancer Cell, Nov 3;16(5):413-24. (*: co-first author)

Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014 Feb 6;506(7486):52-7.

Kochupurakkal BS, Iglehart JD. Nourseothricin N-acetyl transferase: a positive selection marker for mammalian cells. PLoS One. 2013 Jul 4;8(7):e68509.

Li Y, Iglehart JD, Richardson AL, Wang ZC. The amplified cancer gene LAPTM4B promotes tumor growth and tolerance to stress through the induction of autophagy. Autophagy. 2012 Feb 1;8(2):273-4.

Walczak MA, Hayashida J, Danishefsky SJ. Building biologics by chemical synthesis: practical preparation of di- and triantennary N-linked glycoconjugates. J Am Chem Soc. 2013 Mar 27;135(12):4700-3.

Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER Jr, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet. 2014 Feb;46(2):161-5.

Vora SR, Juric D, Kim N, Mino-Kenudson M, Huynh T, Costa C, Lockerman EL, Pollack SF, Liu M, Li X, Lehar J, Wiesmann M, Wartmann M, Chen Y, Cao ZA, Pinzon-Ortiz M, Kim S, Schlegel R, Huang A, Engelman JA. CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors. Cancer Cell. 2014 Jul 14;26(1):136-49.

Anczuków et al., SRSF1-Regulated Alternative Splicing in Breast Cancer Mol Cell. 2015 Oct 1;60(1):105-17.

Javier et al., AKT signaling in ERBB2-amplified breast cancer. Pharmacol Ther. 2016 Feb;158:63-70. doi: 10.1016/j.pharmthera.2015.11.013. Epub 2015 Dec 2.

Pavlova and Thompson, The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 2016 Jan 12;23(1):27-47. doi: 10.1016/j.cmet.2015.12.006.

Toska and Baselga, Pharmacology in the Era of Targeted Therapies: The Case of PI3K Inhibitors. Clin Cancer Res. 2016 Mar 8. pii: clincanres.0038.2016.

Rossetti et al., Harnessing 3D models of mammary epithelial morphogenesis: An off the beaten path approach to identify candidate biomarkers of early stage breast cancer. Cancer Lett. 2016 Oct 1;380(2):375-83. doi: 10.1016/j.canlet.2016.07.003.

Rossetti  et al., Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery. Cell Cycle. 2016 Sep 16;15(18):2515-26. doi: 10.1080/15384101.2016.1215385.

Rossetti et al., Tracing anti-cancer and cancer-promoting actions of all-trans retinoic acid in breast cancer to a RARα epigenetic mechanism of mammary epithelial cell fate. Oncotarget. 2016 Dec 27;7(52):87064-87080. doi: 10.18632/oncotarget.13500.

Carmona et al., AKT signaling in ERBB2-amplified breast cancer. Pharmacol Ther. 2016 Feb;158:63-70. doi: 10.1016/j.pharmthera.2015.11.013. Epub 2015 Dec 2.

Page et al., Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy. Cancer Immunol Res. 2016 Oct;4(10):835-844. Epub 2016 Sep 1.

Toska and Baselga, Pharmacology in the Era of Targeted Therapies: The Case of PI3K Inhibitors. Clin Cancer Res. 2016 May 1;22(9):2099-101. doi: 10.1158/1078-0432.CCR-16-0038. Epub 2016 Mar 8.

Ilic et al., PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10.

Zhang J, Pavlova and Thompson, Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. EMBO J. 2017 May 15;36(10):1302-1315. doi: 10.15252/embj.201696151. Epub 2017 Apr 18.

Toska et al., PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science. 2017 Mar 24;355(6331):1324-1330. doi: 10.1126/science.aah6893.

Hofstatter et al., Increased epigenetic age in normal breast tissue from luminal breast cancer patients. Clin Epigenetics. 2018 Aug 29;10(1):112. doi: 10.1186/s13148-018-0534-8.

Kale, J, Kutuk, O et al., Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. EMBO Rep. 2018 Sep;19(9). pii: e45235. doi: 10.15252/embr.201745235. Epub 2018 Jul 9

Carlson, P, Dasgupta A et al., Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy. Nat Cell Biol. 2019 Feb;21(2):238-250. doi: 10.1038/s41556-018-0267-0. Epub 2019 Jan 21

Li J, et al. An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer. Elife. 2018 Jul 30;7. pii: e37184. doi: 10.7554/eLife.37184.

Zhang J, Pavlova NN, Thompson CB. Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. EMBO J. 2017 May 15;36(10):1302-1315. doi: 10.15252/embj.201696151. Epub 2017 Apr 18. Review.

Robinett RA, Guan N, Lux A, Biburger M, Nimmerjahn F, Meyer AS. Dissecting FcγR Regulation through a Multivalent Binding Model. Cell Syst. 2018 Jul 25;7(1):41-48.e5. doi: 10.1016/j.cels.2018.05.018. Epub 2018 Jun 27.

Albrengues J,et al., Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018 Sep 28;361(6409). pii: eaao4227. doi: 10.1126/science.aao4227.

Karaayvaz M, Cristea S, Gillespie SM, Patel AP, Mylvaganam R, Luo CC, Specht MC, Bernstein BE, Michor F, Ellisen LW. Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq. Nat Commun. 2018 09 04; 9(1):3588.


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